You really have to approach this on a language to language and country to country basis. Think out of the box and ensure the site is build from the start with the aim of using a (local!)domain per language/country and not one domain for the entire site.
So you either end up with multiple sites integrated into one another and technically being one site (in the back-end) or multiple sites linking to each other. Either way can be done fine without degrading the visitor's experience on the site.

Getting indexed in the local search engines is very simple, competing for the competitive local phrases, now that is a different story!